自免疫性疾病和呼吸道疾病在儿科人口之间的关系
Joshua M Sorrentino1, Sedale Boire2, Gaayathri Varavenkataraman3
1Jacobs School of Medicine and Biomedical Sciences, 955 Main St, Buffalo, NY, 14203, USA; UBMD Department of Otolaryngology, 8207 Main St Suite #5, Williamsville, NY, 14221, USA.
患有自身免疫性疾病 (AD) 的儿科患者患有炎症性呼吸道疾病 (IRC) 的风险明显更高,包括慢性鼻炎 (CRS) 和喘. 这强调了需要提高临床意识和进一步研究早期干预策略的必要性.
科学领域:
- 儿科免疫学 儿科免疫学
- 呼吸系统药物 呼吸系统药物
- 自身免疫性疾病是一种自身免疫性疾病.
背景情况:
- 自免疫性疾病 (AD) 涉及免疫系统失调.
- 炎症性呼吸道疾病 (IRC) 可以是急性或慢性.
- 儿童的AD和IRC之间的联系需要进一步调查.
研究的目的:
- 调查儿科自身免疫性疾病 (AD) 和炎症性呼吸道疾病 (IRCs) 之间的关联.
- 要确定AD是否会比急性IRC (如急性鼻炎) 增加慢性IRC (如慢性鼻炎) 的风险.
主要方法:
- 来自TriNetX美国协作网络的儿科队列 (2-17岁) 的回顾性分析.
- 1: 1匹配的儿童队列与AD与非AD对照.
- 评估CRS,ARS,上呼吸道感染和喘的患病率;对IRC患者的AD存在进行反向分析.
主要成果:
- 患有阿尔茨海默病的儿童患有IRC的几率显著增加,包括CRS (OR=2.09),ARS (OR=1.75),慢性鼻炎 (OR=1.86),喘 (OR=1.86).
- 反向分析证实,在CRS和ARS患者中,阿尔茨海默病的几率较高.
- 特定的AD,如死性血管病变 (OR=3.93) 和全身性红斑狼 (OR=3.28) 与IRC有很强的关联.
结论:
- 患有自身免疫性疾病的儿科患者面临炎症性呼吸道疾病的风险增加.
- 研究结果表明,在这个人群中需要提高临床警.
- 需要进一步的研究来阐明机制,并探索在患有AD的儿童中IRC的早期干预.
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