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在2021年热圆顶期间探索药物和与热有关的社区死亡之间的关系:使用机器学习的混合方法
Jeremie Boudreault1, Kathleen E McLean2, Sarah B Henderson2
1Environmental Health Services, British Columbia Centre for Disease Control, 655 West 12th Ave, Vancouver, BC, V5Z 4R4, Canada; Centre Eau Terre Environnement, Institut national de la recherche scientifique, 490 de la Couronne, Québec, QC, G1K 9A9, Canada.
EBioMedicine
|June 11, 2025
概括
某些药物在极端高温事件 (EHE) 中增加死亡风险. 抗药和糖尿病药物与较高的死亡率有关,而通道阻断剂显示有保护作用.
科学领域:
- 环境健康 环境健康
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 极端高温事件 (EHEs) 构成了全球严重的健康风险.
- 关于药物在EHE死亡率中的作用的研究是有限的.
- 了解热浪期间的制药影响对于公共卫生至关重要.
研究的目的:
- 调查发行药物和极端高温事件 (EHE) 期间死亡率之间的关联.
- 确定可能增加或减少与热有关的死亡风险的特定药物类别.
- 使用后勤回归 (LR) 和机器学习 (ML) 进行全面分析.
主要方法:
- 使用来自加拿大不列颠哥伦比亚省的相关行政健康数据,采用了病例控制研究设计.
- 在2021年EHE期间,504名社区死亡人数与2520名幸存者相比.
- 在死亡/EHE结束前30,60和90天内发行的药物被使用解剖治疗化学 (ATC) 分类来分析.
主要成果:
- 后勤回归表明,抗药,抗帕金森药,精神病药,利尿药,糖尿病药,β阻塞剂,止痛药,泌尿器药和骨疾病治疗的死亡率增加.
- 通道阻塞剂和眼科药物显示出一种保护性关联.
- 机器学习模型确定了导致风险的关键药物子类,在性别和年龄组中观察到差异.
结论:
- 这项研究有效地结合了LR和ML,以分析EHEs期间药物对死亡率的影响.
- 这些发现有助于了解在极端高温期间的制药风险和保护作用.
- 结果可以为面临风险的人群提供有针对性的公共卫生信息.
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