羊的粘膜屏障功能和小肠的微生物群体对食能量度的反应
1Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Animal : an international journal of animal bioscience
|June 11, 2025
概括
在羊的饮食中增加食能量度可以增强肠道屏障功能和免疫反应. 最佳代谢能量 (ME) 水平似乎高于10.4 MJ/kg DM,以改善肠道健康.
科学领域:
- 动物科学动物科学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 动物的肠道屏障和免疫反应受饮食能量水平的影响.
- 了解最佳能量度对于羊的肠道健康至关重要.
研究的目的:
- 为了确定羊肠道健康的最佳饮食代谢能量 (ME) 度.
- 为了研究变化的ME对绵羊小肠微生物群,屏障功能和粘膜免疫力的影响.
主要方法:
- 四十五只绵羊在45天内被食ME度从8.0到10.4MJ/kg DM的饮食.
- 肠道屏障蛋白质 (Claudin-7, zonula occludens-1),菌素-2,溶酶和免疫因子 (IL-10,TGF-β1,SIgA) 的数量得到量化.
- 用测序分析了小肠道微生物群的组成,重点是阴和阴.
主要成果:
- 增加的饮食ME线性增强了肠道屏障蛋白,粘素-2,溶酶和免疫因子 (IL-10,TGF-β1,SIgA).
- 饮食ME改变了阴茎微生物群,减少了Sacharofermentans,增加了Romboutsia和Succinivibrio.
- 特定的微生物变化与改善的屏障功能标志物 (Claudin-4,Claudin-7,SIgA) 有正相关.
结论:
- 饮食中能量度升高改善了绵羊小肠的物理,化学和免疫障碍.
- 这些改善与肠道微生物社区结构的变化有关.
- 在羊中改善肠道健康的最佳ME度可能高于10.4 MJ/kg DM.
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