Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Complement System01:27

Complement System

2.3K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.3K
Humoral Immune Responses01:36

Humoral Immune Responses

72.2K
Overview
72.2K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

5.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K
Antibody Actions01:26

Antibody Actions

1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K
Complementation Tests00:49

Complementation Tests

4.9K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.9K
Antimicrobial Proteins01:23

Antimicrobial Proteins

947
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
947

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and Candida escape.

Nature communications·2026
Same author

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet-induced obesity.

Clinical & translational immunology·2026
Same author

Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response.

Science immunology·2026
Same author

ROS breaks the cofilin lock on NLRP3.

Nature immunology·2026
Same author

NeuO-mediated O-acetylation of uropathogenic <i>Escherichia coli</i> K1 capsule enhances resistance to phage and neutrophil killing.

Journal of bacteriology·2026
Same author

NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress.

Molecular cell·2025
Same journal

Targeting cholesterol esterification sensitizes liver cancer to CD8<sup>+</sup> T cell attack by impairing metabolic and redox resilience.

Immunity·2026
Same journal

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same journal

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors.

Immunity·2026
Same journal

B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

Immunity·2026
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
查看所有相关文章

相关实验视频

Updated: Jun 13, 2025

Conjunctival Commensal Isolation and Identification in Mice
07:52

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

4.4K

病:为一个补充物而死去.

Jared R Coombs1, Sabrina S Burgener1, Kate Schroder1

  • 1Institute for Molecular Bioscience, The University of Queensland, St Lucia QLD 4072, Australia.

Immunity
|June 11, 2025
PubMed
概括
此摘要是机器生成的。

研究人员在红细胞中发现了一种新的编程细胞死亡途径,称为spectosis. 补剂激活触发了这个过程,导致细胞死亡和血液溶解在血液溶解性疾病.

更多相关视频

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
09:58

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

4.9K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.1K

相关实验视频

Last Updated: Jun 13, 2025

Conjunctival Commensal Isolation and Identification in Mice
07:52

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

4.4K
Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
09:58

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

4.9K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.1K

科学领域:

  • 细胞生物学 细胞生物学
  • 免疫学 免疫学 免疫学
  • 血液学 血液学 血液学

背景情况:

  • 红细胞 (RBC) 对于运输氧气至关重要.
  • 红细胞的病态细胞死亡有助于溶血性疾病.
  • 了解红细胞死亡机制对于疾病治疗至关重要.

研究的目的:

  • 为了阐明红细胞中的新型编程细胞死亡途径.
  • 为了研究背后的分子机制spectosis.
  • 为了确定血液溶解性疾病的潜在治疗点.

主要方法:

  • 利用先进的显微镜和生物化学分析.
  • 在红细胞中研究了补充激活通路.
  • 分析了 (迷你) NLRP3-caspase-8复合体在细胞死亡中的作用.

主要成果:

  • 在红细胞中发现了一种新型的编程细胞死亡途径,称为红细胞谱化.
  • 证明了补充剂激活启动了光.
  • 表明 (迷你) NLRP3-caspase-8 复合体是光谱化途径的核心.
  • 在疾病的背景下,与血液溶解相关的光.

结论:

  • 乳病代表了一个独特的程序化的红细胞死亡模式.
  • 补充介导的光有助于疾病中的血液溶解.
  • 向光症可能为血液溶解障碍提供新的治疗策略.