在儿科急性呼吸窘迫综合征中,Olfactomedin-4的升高
Ryan O'Sullivan1, Matthew N Alder2, Celeste G Dixon1
1Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
概括
奥尔法托美丁-4 (OLFM4),一个中性粒细胞标记物,与儿科急性呼吸困扰综合征 (ARDS) 的更糟糕结果有关. 较高的OLFM4水平与ARDS儿童的死亡率增加和器官功能障碍相关.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 免疫学 免疫学 免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 中性粒细胞在急性呼吸困扰综合征 (ARDS) 中至关重要.
- 奥尔法托美丁-4 (OLFM4) 是一种中性粒细胞标志物,与儿科败血症的不良结果有关.
- 之前,OLFM4尚未在儿科ARDS中进行研究.
研究的目的:
- 研究血OLFM4水平与儿科ARDS的结果之间的关联.
- 检查OLFM4与死亡率,无透析生存率和无呼吸器日的关系.
- 探索脂多糖 (LPS) 和基因组对OLFM4表达的体外影响.
主要方法:
- 对333名患有柏林定义的ARDS儿童的前性队列的二次分析.
- 血OLFM4水平测定在ARDS的第0天.
- 多变量回归调整为年龄,ARDS病因,免疫功能受损状态和PaO2/FiO2比率.
- 在体外实验中评估OLFM4表达在暴露于LPS和组织蛋白的中性粒细胞中的实验.
主要成果:
- 在非幸存者,严重ARDS,高炎症ARDS和多器官衰竭中观察到较高的OLFM4水平.
- 多变量分析显示,OLFM4与增加的死亡率,更高的透析可能性和更少的无呼吸器日有关.
- 在体外,素H3暴露增加了中性粒细胞中的OLFM4表达,部分受到TLR对抗的抑制.
结论:
- 血OLFM4与儿科ARDS的较差结果有关.
- 希斯H3可能会诱导中性粒细胞中的OLFM4表达,将DAMP与中性粒细胞功能联系起来.
- 在儿童ARDS中,OLFM4代表了一个潜在的治疗点.
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