性临床试验期间增加的联合激活与脑中反应平衡控制期间增加的联合激活有关
Jente Willaert1, Lena H Ting2,3, Anja Van Campenhout4
1Department of Movement Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium.
Journal of neurophysiology
|June 11, 2025
概括
患有脑 (CP) 的儿童在脚旋转时表现出增加的协同激活,这预示着平衡控制受损. 这表明,减少相互抑制可能会影响CP中的反应平衡.
科学领域:
- 神经科学是一个神经科学.
- 生物力学 生物力学
- 儿科 儿科 儿科
背景情况:
- 关节高抗性是脑 (CP) 的常见症状.
- 这种超强阻力可能会导致反应平衡障碍.
- 了解肌肉对关节旋转的反应对于CP研究至关重要.
研究的目的:
- 研究肌肉对单独脚旋转的反应与CP儿童站立平衡扰乱之间的关系.
- 为了比较患有CP的儿童和典型发育的儿童之间的这些关系.
- 确定CP中改变反应平衡控制的潜在预测因素.
主要方法:
- 20名患有脑膜异位症的儿童和20名典型发育的儿童参与了这项研究.
- 脚关节旋转在仪器化性评估期间进行.
- 使用支表面转移和旋转来扰乱常态平衡.
- 测量了胃角肌,肌和前肌的电肌图.
- 评估了平侧 flexor-dorsiflexor 协同激活和神经应对伸展的反应.
- 线性混合模型被用来分析肌肉反应和平衡扰乱之间的关系.
主要成果:
- 在孤立关节旋转和平衡扰乱期间的协同激活在患有CP的儿童中具有显著的相关性,但在典型发育的儿童中没有.
- 在单独的关节旋转期间的神经应对伸展和两组平衡扰动之间没有发现显著的相关性.
- 在隔离关节旋转期间增加的协同激活可能预测CP中反应平衡控制策略的改变.
结论:
- 在隔离关节旋转期间增加的联合激活,可能是由于相互抑制减少,与CP儿童的反应平衡控制改变有关.
- 这一发现表明,在被动关节运动期间的协同激活可以作为CP平衡赤字的预测指标.
- 对相互抑制机制的进一步研究是有必要的,以开发有针对性的干预措施,以改善CP的平衡.
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