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Updated: Jun 13, 2025

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甲基醇诱导的RNA修饰降低了RNA的稳定性和翻译性,并与2型糖尿病有关

Edwin De Jesus Lopez Gonzalez1, Seigmund Wai Tsuen Lai1, Kelani Sun1

  • 1Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, United States.

Molecular metabolism
|June 11, 2025
PubMed
概括

甲基醇修改RNA,形成像CEG这样的添加物,这种添加物在2型糖尿病中升高,并与并发症有关. 这种RNA损伤会影响mRNA的稳定性和翻译性,揭示出一种新的疾病标志物.

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