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来自海洋来源的Trichoderma harzianum CS-152的高氧化酸

Yan-He Li¹, Xiao-Ming Li², Xin Li²

¹CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Wenhai Road 1, Qingdao 266237, China; University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China.

|June 11, 2025

概括

从深海真菌中分离出了三种新的基烯. 两种化合物表现出对Aeromonas hydrophila的抗菌活性,另一种对Pseudomonas aeruginosa的抗菌活性.

科学领域:

海洋天然产品化学海洋天然产品化学
的二次代谢产物的二次代谢产物
发现抗微生物药物发现.

背景情况:

深海真菌是新型生物活性化合物的有希望的来源.
特里科德尔马·哈尔齐安 (Trichoderma harzianum) 已经产生了各种具有多样化生物活性的基.
高氧化通常表现出独特的化学结构和药理性质.

研究的目的:

从深海真菌Trichoderma harzianum CS-152中分离和表征新的甲.
评估隔离化合物对关键水生和人类病原体的抗菌潜力.
为了探索来自海洋的真菌的acorane sesquiterpenes的结构多样性.

主要方法:

使用石凝柱色谱进行隔离和净化.
通过全面的光谱分析 (1D/2D NMR,HRESIMS) 阐明结构.
使用修改后的莫舍尔法确定绝对配置.

主要成果:

确定了三种新的高氧化甲烯 (1-3) 和四种已知的类似物 (4-7).
化合物1和4显示出对Aeromonas hydrophila (MIC = 4μg/mL) 的显著抑制活性.
化合物7对Pseudomonas aeruginosa表现出抗菌活性 (MIC = 4μg/mL).

结论:

深海的真菌Trichoderma harzianum CS-152产生了新型的.
隔离的化合物具有显著的抗菌作用,对特定的病原体.
这项研究扩大了海洋衍生的真菌代谢物的化学多样性,并突出了它们的治疗潜力.

关键词:

亚科兰是六二二烯的.具有抗菌活性,具有抗菌活性.寒冷的入 - - 这就是冷静的入.深海衍生的真菌真菌来源于深海.三皮虫 (Trichoderma harzianum) 是一种有毒的动物.

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