长期的多系统性后续后住院治疗Omicron COVID-19与流感:一个回顾性队列研究
Liang En Wee1, Reen Wan Li Ho2, Jue Tao Lim3
1National Centre for Infectious Diseases, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore; Department of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore.
概括
与流感相比,COVID-19住院的心脏风险较低,但认知障碍和疲劳的风险较高,特别是在未接种疫苗的人群中. 疫苗接种对于这两种疾病至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在COVID-19住院后的长期健康后果 (后续),特别是由Omicron变种引起的后果,需要与其他呼吸道感染 (如季节性流感) 进行比较.
- 疫苗接种情况对这些长期结果的影响是了解疾病负担的关键因素.
研究的目的:
- 为了比较COVID-19住院后的长期后果 (Omicron变种) 与季节性流感住院后的长期后果.
- 根据COVID-19和流感疫苗接种状态来分层这些比较.
主要方法:
- 在新加坡进行了一项以人口为基础的回顾性队列研究.
- 数据包括成人COVID-19住院情况 (2022年1月至2023年9月) 和流感住院情况 (2017年1月至2023年9月).
- 使用重叠加权重竞争风险回归来估计后急性诊断/症状 (31-300天后出院) 的风险,死亡是竞争风险.
主要成果:
- 与流感相比,在COVID-19住院后观察到急性后心脏症状和疾病的风险较低,特别是在增强和接种疫苗的人群中.
- 相反,在COVID-19住院后与流感相比,经过急性认知障碍和疲劳/不适的风险显著更高,特别是在未增强/未接种疫苗的个体中.
- 具体发现包括COVID-19后认知障碍 (1.34) 和疲劳/不适 (1.75) 的更高调整后危险比率与流感.
结论:
- COVID-19 住院治疗与认知障碍和疲劳的风险增加有关,但与流感相比,心脏病后果的风险较低,特别是在未接种疫苗或未增强疫苗的个体中.
- 这些发现强调了这些病毒感染的不同长期影响.
- 持续强调COVID-19和流感疫苗接种对于减轻这些疾病流行阶段的长期健康后果至关重要.
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