根的口腔微生物组:一个范围审查
Ronnie Ruonan Zhang1, Josie Shizhen Zhang1, Shi Huang1
1Faculty of Dentistry, The University of Hong Kong, Hong Kong, S.A.R., China.
Journal of dentistry
|June 11, 2025
概括
根的口腔微生物群与健康的表面不同,特定的细菌促进酸性生产和组织分解. 这种理解可以为根的新预防和治疗策略提供信息.
科学领域:
- 微生物学 微生物学
- 牙科研究 牙科研究
- 口腔健康 口腔健康
背景情况:
- 根 кариес是一个重要的口腔健康问题.
- 了解口腔微生物群对于解决根病至关重要.
- 之前的研究已经探索了牙腐烂中的微生物转移,但根腐烂需要具体的调查.
研究的目的:
- 描述与健康根表面相比,状根表面的口腔微生物群落的变化.
- 为了确定与根相关的占主导地位的微生物物种和功能途径.
- 为未来根的预防和治疗策略提供见解.
主要方法:
- 在2025年4月1日之前对英语出版物进行系统的文献搜索.
- 包括使用高通量测序技术的临床研究.
- 搜索的数据库:PubMed,Cochrane,科学网,Embase,Scopus,临床试验.gov,谷歌学者. 在这些数据库中进行了搜索.
主要成果:
- 包括8项研究,分析了根病患者的口腔微生物组数据.
- 在状和健全的根表面之间没有在α-多样性上发现一致的显著差异.
- 在三项研究中,β多样性有显著差异,表明了组成的变化.
- 在根中经常发现的细菌包括Lactobacillus spp.,Prevotella denticola,Streptococcus mutans.
- 相关细菌促进有机酸的产生和原体的降解.
结论:
- 根腐菌微生物体表现出不同的组成形状和异生物物种的占主导地位.
- 功能途径发生变化,有利于酸性生产和组织降解.
- 研究结果为开发针对根的有针对性的预防和治疗干预措施提供了宝贵的见解.
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