母体甲状腺激素水平与与怀孕相关的焦虑对出生结果的相互作用 - 一个出生队列研究
Penggui Wu1, Jiajun Ouyang1, Wenjin Cai1
1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, No 81 Meishan Road, Hefei 230032, Anhui, China.
母亲的甲状腺激素水平和与怀孕有关的焦虑相互作用,影响出生体重和妊娠年龄. 持续低的甲状腺激素和高的焦虑可能会增加孕期婴儿大大的风险.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 心理神经内分泌学心理学
背景情况:
- 母亲的甲状腺激素和与怀孕相关的焦虑 (PRA) 影响怀孕的结果.
- 这些因素对出生结果的相互作用影响尚未得到充分理解.
研究的目的:
- 研究母体甲状腺激素水平和PRA对分娩结果的联合影响.
- 为了探索甲状腺功能和怀孕期间焦虑之间的潜在相互作用.
主要方法:
- 1,798对母婴对的前性队列研究 (马安山出生队列).
- 在所有三个季度评估PRA和甲状腺激素水平 (自由甲状腺素-FT4).
- 对与出生体重和妊娠年龄类别 (LGA,SGA) 的关联和相互作用的分析.
主要成果:
- 第二和第三个三个月的FT4水平与出生体重负相关,并降低了妊娠年龄大 (LGA) 的风险.
- 在第三个三个月的高PRA增加了怀孕年龄小 (SGA) 婴儿的风险.
- 相互作用表明,较高的FT4降低了非焦虑女性的LGA风险,而持续的低FT4和高焦虑增加了LGA风险.
结论:
- 孕期甲状腺激素水平和PRA可能会相互作用,影响分娩结果.
- 持续低甲状腺激素水平加上怀孕期间的慢性高焦虑与LGA婴儿的风险增加有关.
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