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Updated: Jun 13, 2025

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

全转录组基因年龄相互作用研究和多组组综合分析揭示了NLRC4在衰老过程中对HNSCC预后和免疫微环境的异质调节

Ziang Xu¹, Maojie Xue², Yuqing Yang²

¹State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China; Department of the Ninth Outpatient, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

International journal of biological macromolecules

|June 11, 2025

概括

这项研究表明,NLRC4基因与年龄相互作用,影响头部和部状细胞癌 (HNSCC) 的存活率. 了解这些复杂的相互作用可以为HNSCC患者指导个性化治疗策略.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
免疫学免疫学免疫学

背景情况:

头部和部状细胞癌 (HNSCC) 在治疗反应中表现出与年龄相关的显著变化.
有效的预测生物标志物对于改善老年HNSCC患者的生存率至关重要.
基因表达对有关年龄的HNSCC预后的影响仍然在很大程度上未被探索.

研究的目的:

调查基因表达对HNSCC.总体存活时间的年龄相关影响.
为了确定特定的基因,其表达改变了年龄对HNSCC预后的影响.
探索HNSCC中基因表达,年龄和免疫/细胞外矩阵因子之间的相互作用.

主要方法:

从HNSCC患者队列 (TCGA,GEO,ArrayExpress) 的多中心转录组数据的整合.
全基因组分析,以识别具有年龄改变对生存的影响的基因.
多组数据分析,以评估与免疫相关的指标和巨细胞两极分化.
涉及NLRC4,年龄和细胞外矩阵 (ECM) 相关基因的三向相互作用分析.

主要成果:

在多个数据集中,NLRC4基因对HNSCC总体存活率表现出显著的年龄变异效应.
在低NLRC4表达和衰老之间观察到对抗性相互作用.
NLRC4表达与免疫细胞群,特别是单细胞/巨细胞和M1/M2极化有关.
与双向相互作用相比,涉及NLRC4,年龄和ECM基因 (原体) 的三向相互作用显著改善了预后准确性.

结论:

NLRC4是一种关键基因,其对HNSCC的预后影响因患者年龄而显著调节.
在NLRC4,年龄和ECM基因之间发现的复杂相互作用为HNSCC进展提供了新的见解.
这些发现突出了NLRC4作为改善HNSCC患者结果的潜在治疗点,特别是在老年人群中.

关键词:

基因与年龄的相互作用.头部和部状细胞癌瘤免疫的景观.巨细胞的两极分化总体生存率总体生存率三方互动是三方的互动.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...