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使用Gliadin-Carboxymethyl chitosan复合纳米粒子开发自组装 (+) -Nootkatone输送系统:制造,表征和制药应用

Jie Huang¹, Fei Wang¹, Yu Zhang¹

¹National Key Laboratory for the Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China.; Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.

International journal of biological macromolecules

|June 11, 2025

概括

这项研究开发了Gliadin/Carboxymethyl chitosan (CMCS) 纳米颗粒,以改善 (+) -nootkatone (NK) 的口服生物可用性和稳定性. 复合纳米颗粒有效封装NK,增强其功能性食品和补充剂的治疗潜力.

科学领域:

材料科学材料科学材料科学
生物技术是生物技术.
药理学药理学是指药理学的学科.

背景情况:

(+) -nootkatone (NK) 具有显著的治疗潜力,但由于溶解度低和不稳定性,其口服生物利用性较差.
有效的交付系统对于克服这些局限性和利用NK的好处至关重要.

研究的目的:

开发和描述Gliadin/Carboxymethyl chitosan (CMCS) 复合纳米颗粒,用于增强 (+) -nootkatone (NK) 的口服输送.
为了评估NK在开发的纳米粒子中封装的稳定性,受控释放和生物活性.

主要方法:

使用抗溶剂沉方法制备了装载NK的Gliadin/CMCS复合纳米颗粒.
纳米粒子的特征包括尺寸,泽塔潜力,形态 (显微镜) 和封装效率.
在体外研究中评估了NK的稳定性,受控释放,抗氧化和抗癌活性.

主要成果:

格里亚丁/CMCS纳米粒子 (4:1比) 的平均尺寸为224.4nm,泽塔电位为-31.0mV,NK封装效率为81.9%.
封装显著改善了NK的环境稳定性,热强度和受控释放特征.
复合纳米粒子增强了NK的自由基清除和抗癌活动,改善了体外消化释放.

结论:

格里亚丁/CMCS复合纳米颗粒是一种有效的系统,可以提高 (+) - 诺卡 (NK) 的口服生物可用性和稳定性.
这些纳米粒子在功能性食品,饮料和营养保健品中的应用是有前途的.

关键词:

(+) -诺特卡是一种碳氧甲基基托桑是一种碳氧甲基基托桑.交付系统的交付系统.格里亚丁蛋白是什么格里亚丁蛋白是什么纳米颗粒纳米颗粒

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