实时数字干预MSM口服预暴露预防:随机对照试验
Zhen-Xing Chu1,2,3,4, Xia Jin5, Ze-Hao Ye6
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Centre for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, 110001, China.
NPJ digital medicine
|June 11, 2025
概括
数字干预显著改善了与男性发生性关系的男性在六个月内遵守口服暴露前预防药物 (PrEP) 的情况. 这种方法提高了坚持不增加高风险的性行为.
科学领域:
- 公共卫生 公共卫生
- 数字健康数字健康
- 预防艾滋病毒 预防艾滋病毒
背景情况:
- 口服暴露前预防 (PrEP) 是有效的预防艾滋病毒在与男性发生性关系的男性 (MSM).
- 在现实世界中,遵守口服PrEP方案是一个重大挑战.
- 数字干预提供了一个潜在的解决方案,以改善药物坚持.
研究的目的:
- 评估实时数字干预在增强MSM口服PrEP遵守方面的有效性.
- 评估数字干预对高风险性行为和物质使用的影响.
主要方法:
- 进行了一项随机对照试验,涉及442名MSM.
- 参与者被分配到干预组或对照组.
- 电子药物监测器被用来客观地测量PrEP在6个月的随访期间的坚持.
主要成果:
- 与对照组 (59.8%) 相比,干预组表现出明显更高的口服PrEP坚持 (83.1%) .
- 经调整后,依从度的净差异为21.0% (95% CI:12.9-29.2%,p < 0.001).
- 两组之间在性伴侣数量,无避孕套的交或物质使用障碍方面没有发现显著差异.
结论:
- 实时数字干预有效地改善了MSM在6个月内口服PrEP的坚持.
- 该干预措施在每日和事件驱动的PrEP疗程中都显示出有效性.
- 数字干预没有影响高风险行为,这表明只对坚持有针对性的影响.
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