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肝细胞癌中的免疫微环境:从致病源到免疫疗法

Deniz Seyhan^1,2, Manon Allaire^3,4,5, Yaojie Fu²

¹Doctoral School of "Physiologie, Physiopathologie & Thérapeutique", Sorbonne Université, Paris, France.

Cellular & molecular immunology

|June 11, 2025

概括

肝细胞癌 (HCC) 的进展是由其复杂的瘤微环境 (TME) 驱动的. 了解TME中的免疫细胞对于开发新型免疫疗法来治疗这种致命的肝癌至关重要.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

肝细胞癌 (HCC) 是一种流行且致命的肝癌,具有多种病因因素,包括与酒精相关的肝病 (ALD) 和与代谢功能障碍相关的脂肪肝炎 (MASH).
在HCC中,瘤微环境 (TME) 是一个复杂的生态系统,包括各种免疫和纤维细胞,影响癌症发病,进展和转移.

研究的目的:

审查目前对免疫和纤维细胞在HCC瘤微环境中的直接和间接作用的理解.
突出新型实验技术和动物模型来阐明HCC TME.
讨论新兴的基于免疫的治疗策略,用于HCC治疗和疗效预测.

主要方法:

文献综述侧重于最近关于免疫细胞群 (先天性和适应性) 和肝脏星状细胞在HCC发病过程中的发现.
探索先进的实验技术和动物模型用于TME表征.
对HCC的当前和新兴免疫治疗方法的分析.

主要成果:

HCC TME包括各种先天性免疫细胞 (巨细胞,NK细胞等). 和适应性免疫细胞 (CD4+,CD8+T细胞等). ),以及像肝星状细胞这样的纤维质细胞.
这些细胞成分显著影响HCC的发病,进展和转移.
新的技术和模型正在开发中,以更好地理解和准复杂的HCC TME.

结论:

进一步描述异构的HCC TME对于进一步研究HCC进展至关重要.
了解TME内部复杂的细胞相互作用对于开发有效的免疫疗法至关重要.
新兴的基于免疫的策略对治疗HCC和预测治疗反应具有前景.

关键词:

肝细胞癌是肝细胞癌.免疫微环境是一个微环境.免疫疗法.免疫疗法.

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