作为潜在的抗癌剂的普罗亚尼丁:作用机制,生物可用性挑战和治疗机会
Adedayo O Ademiluyi1, Olubukola H Oyeniran2, María Luisa Del Prado-Audelo3
1Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, 340252, Nigeria.
Medical oncology (Northwood, London, England)
|June 11, 2025
概括
普罗亚尼丁 (PCs),天然的多,通过向关键细胞通路并诱导亡,显示出显著的抗癌潜力. 提高它们的生物可用性对于癌症治疗中有效的临床应用至关重要.
科学领域:
- 饮食中的多醇研究研究
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 普罗亚尼丁 (PCs) 是一种在各种植物性食品和饮料中发现的饮食多.
- PCs通过各种机制表现出强大的抗癌特性,包括调节氧化应激,抑制血管生成和诱导亡.
- 尽管有前临床和临床发现很有希望,但由于生物可用性和药理动力学方面的挑战,它们的治疗潜力尚未得到充分探索.
研究的目的:
- 为PCs的抗癌性质提供全面的分析.
- 审查它们的生物可用性,药理动力学和安全性.
- 确定临床应用的挑战和未来方向.
主要方法:
- 在PubMed,Scopus和Web of Science中进行系统的文献搜索.
- 包括基于体外,体内和临床证据的研究.
- 分析PC机制,包括途径调节和亡调节.
主要成果:
- 通过抑制促炎性细胞因子和抑制PI3K/AKT/mTOR和MAPK/ERK等关键信号通路,PC显示出抗癌作用.
- PCs调节与亡相关的蛋白质,如BAX,BCL-2和caspases.
- 低口服生物利用率和代谢不稳定性被确定为临床使用的主要挑战.
结论:
- 需要像纳米颗粒和脂质体这样的新型输送系统来提高PC吸收和有效性.
- 进一步的研究应该集中在优化PC药理动力学和探索与传统癌症疗法的协同效应.
- 作为天然抗癌药物,PC显示出前景,可能补充现有治疗方法并改善患者的治疗结果.
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