表观遗传衰老调解了生命过程中社会经济地位和功能在十年内下降之间的关联
Agus Surachman1,2, Meera N Harhay3,4, Rose Ann DiMaria-Ghalili5
1Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, 3215 Market St, Rm 552, Philadelphia, PA, 19104, USA. as5796@drexel.edu.
GeroScience
|June 11, 2025
概括
表观遗传衰老加速,特别是GrimAge和DunedinPACE,解释了较低的社会经济地位 (SES) 如何随着时间的推移导致功能下降的速度更快. 这突显了慢性病差异的关键途径.
科学领域:
- 生物医学科学 生物医学科学
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 表观遗传衰老措施是生物年龄和慢性疾病风险的新兴生物标志物.
- 整个生命中的社会经济地位 (SES) 与健康结果有关,包括功能.
- 了解连接SES和功能下降的生物学机制对于公共卫生至关重要.
研究的目的:
- 调查表观遗传衰老指数是否调解了生命过程社会经济地位 (SES) 和功能在十年内下降之间的关系.
- 确定特定的表观遗传衰老措施,解释SES和功能下降之间的联系.
主要方法:
- 利用了252名非西班牙裔黑人和白人参与美国中年研究 (MIDUS) 的生物标志物数据.
- 使用家长教育和复合成年SES评分来评估生命历程SES.
- 测量了五种表观遗传年龄加速 (EAA) 和DunedinPACE,以及基于血清肌素的估计膜过率 (eGFR) 对功能.
主要成果:
- 较低的成人SES和加速的表观遗传衰老 (GrimAge,DunedinPACE) 显著调解了父母教育水平较低和eGFR下降率较高之间的关联.
- 加快表观遗传衰老与11年内功能较大下降直接相关.
- 这些发现表明表观遗传衰老途径有助于功能差异.
结论:
- 加快表观遗传衰老是一个重要的解释途径,将较低的社会经济地位与功能下降联系起来.
- 这项研究提供了有关慢性病 (CKD) 在较低SES人群中较高负担的生物学机制的见解.
- 针对表观遗传衰老可能提供新的策略,以减轻功能健康差异.
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