Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Cancer Vaccines01:30

Cancer Vaccines

345
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
345
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

13.9K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
13.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Inactivation of SERCA2 at Cys674 induces skeletal muscle atrophy by activating the TGFβ/Smad-S100a4 axis to promote inflammation.

Redox biology·2026
Same author

An electrochemical sensing platform based on targeted paired binding for biomarker detection in human serum samples.

Biosensors & bioelectronics·2026
Same author

CAV1 up-regulated by peste des petits ruminants virus nucleocapsid protein impairs type I IFN response by cholesterol synthesis.

Veterinary microbiology·2026
Same author

A Comparison of Biosolids Odorants and Odors Emitted from Belt Filter Press and Centrifuge Dewatering.

Water environment research : a research publication of the Water Environment Federation·2026
Same author

Real-time identification of aetiology in patients able to undergo transoesophageal echocardiography with non-traumatic out-of-hospital cardiac arrest in China: a prospective, single-centre exploratory study.

Emergency medicine journal : EMJ·2026
Same author

STARD10 promotes progression of HER2+ breast cancer and intracellular lipid metabolism via the cAMP/PKA/CREB1 signaling axis.

Cancer biology & therapy·2026

相关实验视频

Updated: Jun 13, 2025

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

3.5K

光遗传工程用于精密癌症免疫疗法.

Yuepeng Ke1, Siyao Liu1, Yun Huang2

  • 1Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.

Trends in pharmacological sciences
|June 11, 2025
PubMed
概括

没有素的光遗传学为癌症免疫疗法提供了一种新的方法,可以精确控制免疫反应,以克服治疗耐药性并增强先进精确医学的抗瘤效应.

关键词:
在CAR-T细胞疗法中.癌症治疗 治疗 治疗 癌症免疫工程是一种免疫工程.免疫疗法 免疫疗法视觉遗传学 视觉遗传学合成生物学 合成生物学

更多相关视频

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.4K
Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

16.9K

相关实验视频

Last Updated: Jun 13, 2025

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells
12:04

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

3.5K
Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells
10:57

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

Published on: October 24, 2019

10.4K
Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
06:03

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

16.9K

科学领域:

  • 在瘤学瘤学.
  • 免疫学 免疫学 免疫学
  • 生物技术是生物技术.

背景情况:

  • 癌症免疫疗法已经改变了癌症治疗,但面临着诸如耐药性,耐久性有限,免疫逃避和毒性等挑战.
  • 远程和向免疫调节的创新策略对于克服这些局限性至关重要.

研究的目的:

  • 探索光遗传免疫工程在癌症免疫治疗中的设计策略和应用.
  • 突出无素光遗传学在调节癌症免疫周期的潜力,以获得持续的抗瘤反应.

主要方法:

  • 审查光遗传免疫工程的策略和应用.
  • 专注于无素的光遗传工具,用于精确的免疫调节.
  • 临床前研究的分析,证明了天生的和适应性免疫的调节.

主要成果:

  • 没有素的光遗传学与免疫细胞信号时间尺度保持一致,使多功能免疫调节成为可能.
  • 光遗传免疫工程可以精确调节先天性和适应性免疫.
  • 临床前研究表明,增强和维持抗瘤反应具有前景.

结论:

  • 光遗传免疫工程,特别是使用无素工具,提供了一种强大的方法来增强癌症免疫疗法.
  • 这种方法对通过克服当前免疫治疗的局限性来推进下一代精确医学具有重大前景.