在三级医疗保健机构中,多药耐药性Streptococcus pyogenes的流行率和EMM类型
Abdul Basit1, Mubbashir Hussain2, Muhammad Qasim1
1Department of Microbiology, Kohat University of Science and Technology (KUST), Kohat, 26000, Pakistan.
BMC microbiology
|June 11, 2025
概括
在巴基斯坦,Streptococcus pyogenes感染很常见,其中流行的 emm类型为 emm12, emm4 和 emm1.1. 抗生素耐药性是一个问题,需要针对这一病原体进行有针对性的监测和治疗策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 斯氏菌 (Streptococcus pyogenes) 引起各种感染,由于新兴的抗生素耐药性,这对公共卫生构成威胁.
- 这项研究调查了巴基斯坦Khyber Pakhtunkhwa (KP) 的S. pyogenes,重点关注流行率,抗生素易感性和emm类型.
研究的目的:
- 为了确定S. pyogenes分离物的流行率和抗生素敏感性.
- 为了识别在巴基斯坦KP流通的S. pyogenes菌株的emm类型.
- 了解与S. pyogenes感染相关的风险因素.
主要方法:
- 从KP的八家医院收集了4,062个临床样本.
- 使用标准微生物技术分离并鉴定了S. pyogenes.
- 进行了抗生素敏感性测试 (光盘扩散,E-测试),emm类型 (PCR,DNA测序) 和风险因素的统计分析.
主要成果:
- 在11.5% (471/4062) 的样本中确定了S. pyogenes.
- 最常见的emm类型是emm12 (16%),emm4 (13%) 和emm1 (12%),类型分布因样本来源而异.
- 观察到对红红素 (8%) 和四环素 (8%) 的高耐药性,对青素的耐药性低 (0.6-7.2%). 低财务状况,自我治疗和并发症是显著的风险因素.
结论:
- 在KP中发现了S. pyogenes的显著遗传多样性,以emm12,emm4和emm1为主导类型.
- 观察到的抗生素耐药性模式凸显了持续监测的必要性.
- 针对性的治疗策略对于该地区S. pyogenes感染的有效管理至关重要.
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