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Updated: Jun 15, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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具有甲状腺刺激活性的甲状腺蛋白受体单克隆抗体激活NF-κB通路,诱导化学因表达

Yang Yang1,2, Chen Hui1,2

  • 1Department of Endocrine, The second hospital & clinical medical school,Lanzhou university, Lanzhou, Gansu, China.

Journal of cellular and molecular medicine
|June 11, 2025
PubMed
概括

研究人员开发了三种小鼠抗thyrotropin受体 (TSHR) 单克隆抗体 (mAbs),以了解格雷夫斯病. 这些mAbs刺激TSHR,激活NF-κB信号,并诱导化基因,提供了对自身免疫甲状腺疾病机制的见解.

关键词:
格雷夫斯病 (Graves' disease) 是一种疾病.在 NF-κBB 中.反TSHR的mAbs是什么化学物质化学物质是化学物质.

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