在1925年至2015年间出生的日本人群中,Helicobacter pylori-Naïve患病率的增长趋势:系统性审查和元回归分析
Fumiaki Ishibashi1, Chikamasa Ichita2, Ayaka Takasu3
1Department of Gastroenterology, International University of Health and Welfare Ichikawa Hospital, Ichikawa, Japan.
Helicobacter
|June 12, 2025
概括
杆菌 (H. pylori) 感染与胃癌有关. 在最近的日本出生队伍中,H. pylori-naïve状态的流行率显著增加,在2010年出生的人群中接近98%.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 杆菌 (H. pylori) 是一种已知的致癌物质,与胃癌 (GC) 有关.
- 虽然观察到H. pylori-naïve状态的增加趋势,但代际流行数据仍然未指明.
- 这项研究的重点是确定日本的一代 H. pylori-naïve 流行率.
研究的目的:
- 为了确定日本H. pylori-naïve状态的代际流行率.
- 为不同的出生队列提供精确的流行数据.
- 根据H. pylori感染趋势,为胃癌查策略提供信息.
主要方法:
- 在PubMed和EMBASE的系统文献搜索 (2014年1月 - 2024年6月).
- 包括出版物,说明一代 H. pylori-naïve 的流行情况.
- 使用后勤混合效应模型进行元回归分析,将出生年作为支线函数,研究差异作为随机效应.
主要成果:
- 分析了8本出版物,涉及9个研究小组和46,704名个人.
- 之前没有感染过H. pylori的患病率:21.1% (出生于1930年),47.2% (出生于1950年),75.3% (出生于1970年),91.7% (出生于1990年) 和97.7% (出生于2010年).
- 在最近的出生队伍中观察到H. pylori-naïve状态的显著增加.
结论:
- 之前没有感染过H. pylori的患病率随着最近的出生年数显著增加,在2000年以后出生的人群中稳定在95%以上.
- 这些发现表明当前胃癌查策略的潜在修改.
- 了解代际H. pylori感染趋势对于公共卫生干预至关重要.
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