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Updated: Jun 13, 2025

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被动脱水会增加氧化应激和mTOR信号通路的激活在抵抗运动后的年轻人
Hui-Ying Luk1, Nigel C Jiwan1,2, Casey R Appell1
1Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX, USA.
The Journal of physiology
|June 12, 2025
概括
脱水会增加抵抗运动期间的肌肉压力和生长信号. 保持水分对于最佳的肌肉反应和性能至关重要.
科学领域:
- 运动生理学 运动生理学
- 肌肉生物学 肌肉生物学
- 细胞应激反应的应激反应
背景情况:
- 脱水会对运动表现和肌肉大小产生负面影响.
- 在人类中,将脱水与肌肉反应联系起来的细胞机制尚未完全理解.
- 以前的研究主要依赖于体外研究.
研究的目的:
- 为了研究脱水和无水化训练的男性对抗力运动的肌肉内反应.
- 分析关键的信号通路,压力标志物和肌肉特征.
主要方法:
- 11名抵抗训练的男性接受了两次下体抵抗运动:一个脱水 (DEHY) 和一个无水化 (EUHY).
- 运动前和运动后1小时和3小时收集肌肉样本.
- 分析包括信号蛋白 (AKT/mTOR/p70S6K/rpS6),压力标志物 (REDD1,H2O2),自标志物,甲素L,纤维横截面积 (CSA) 和肌肉水含量.
主要成果:
- 脱水导致休息时rpS6和运动时S6K的激活较大,而非水解.
- 在DEHY条件下观察到肌肉应激标志物 (H2O2,REDD1) 和蛋白质分解活性 (甲素L) 的升高.
- 肌肉水含量在DEHY运动后增加,而纤维CSA与EUHY相比较较小.
结论:
- 在脱水的情况下进行阻力运动会给骨肌肉带来额外的压力.
- 脱水会增加细胞压力,并激活合成代谢信号通路.
- 充足的水分是优化肌肉对抗力运动的反应至关重要的.
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