血清微量元素度与酸诱导的肝毒性之间的关联在患有的儿科患者中
Linfeng Ma1, Qi Liu1, Li Chen1
1Department of Medicine, Shandong College of Traditional Chinese Medicine, Yantai, Shandong, China.
Pakistan journal of pharmaceutical sciences
|June 12, 2025
概括
酸 (VPA) 治疗可能会导致肝损伤. 这项研究发现,较高的铁和较低的和水平与VPA诱导的肝毒性有关,可能是通过氧化应激.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 毒理学 毒理学 毒理学
背景情况:
- 酸 (VPA) 是一种已知具有肝毒性的抗药物.
- 与VPA相关的肝损伤的确切机制尚未完全理解.
研究的目的:
- 调查微量元素和氧化应激在VPA引起的肝毒性中的作用.
- 确定潜在的生物标志物来预测长期接受VPA治疗的患者的肝损伤.
主要方法:
- 从137名接受VPA治疗的患者的血液样本中分析了肝功能,微量元素 (Fe,Co,Se) 和氧化应激标志物.
- 统计分析包括多重和后勤回归来评估微量元素,氧化应激和肝毒性之间的相关性.
主要成果:
- 肝毒性患者的铁 (Fe) 度显著上升, (Co) 和 (Se) 度降低.
- 铁含量与肝酶活动和氧化应激标志物正相关.
- 和水平与肝损伤指标和降低肝毒性风险有负相关性.
结论:
- 微量元素,特别是铁,和,在VPA诱导的肝毒性病变发生过程中发挥作用.
- 氧化应激是参与这一过程的关键途径.
- Fe,Co和Se水平可以作为VPA相关肝损伤的预测标记.
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