开发和评估加巴丁的胃化粘膜粘合微球
Sana Mamona1, Eman Younas1, Shifa Yousaf1
1Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Pakistan journal of pharmaceutical sciences
|June 12, 2025
概括
研究人员使用HPMC和EC聚合物开发了持续释放的 gabapentin 微球. 配方5显示出最佳的粘膜粘合特性和持续16小时的药物释放,改善了加巴丁在和神经病痛治疗中的生物可用性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 和神经病痛是普遍存在的神经疾病,影响全球数百万人.
- gabapentin 是一个关键的治疗剂,但它的有效性可能受到生物可用性和剂量频率的限制.
- 开发先进的药物输送系统对于改善患者的治疗结果至关重要.
研究的目的:
- 开发和分析 gabapentin 持续释放的粘膜粘合微球.
- 使用基甲基纤维素 (HPMC) 和乙基纤维素 (EC) 作为可控制药物释放的聚合物.
- 通过提高生物可用性和延长胃停留时间来增强 gabapentin 的治疗效果.
主要方法:
- 使用溶剂蒸发技术制造了加巴丁微球,HPMC和EC的比例不同.
- 描述包括扫描电子显微镜 (SEM),DSC,IR光谱,胀指数,百分比产量,内容均性,颗粒大小分析,体外药物释放研究和粘膜粘合测试.
- 准备和评估了五种不同的配方.
主要成果:
- 封装效率在82.95%至97.75%之间.
- 配方5 (加巴丁:EC:HPMC, 1:2:3) 在模拟的胃液 (0.1N HCl) 中显示了16小时的最佳持续释放加巴丁,遵循第一阶动力学.
- 微球表现出显著的粘膜粘合性,表明可能延长胃内停留时间和增强生物可用性.
结论:
- 开发的HPMC和EC基 gabapentin微球为口服持续释放提供了一个有前途的方法.
- 配方5代表了一种最佳配方,具有出色的持续释放和粘粘性特征.
- 这些粘膜粘合微球有可能通过增加 gabapentin 的生物可用性和疗效来改善和神经性疼痛的治疗管理.
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