在中年妇女的棕色脂肪组织,肥胖和更年期状态
Daniel E Brown1, Sofiya Shreyer2, Sarah Witkowski3
1Department of Anthropology, University of Hawaii at Hilo, Hilo, Hawaii, USA.
American journal of biological anthropology
|June 12, 2025
概括
绝经后妇女的棕色脂肪组织 (BAT) 活性较低,与中心肥胖和心脏代谢疾病风险增加有关. 这项研究探讨了更年期状态对BAT活性和脂肪度的影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 妇女健康 妇女健康
背景情况:
- 更年期过渡与由于脂肪分布的变化而增加心脏代谢疾病风险有关.
- 棕色脂肪组织 (BAT) 的激活会增加新陈代谢率,并可能防止肥胖,但其在更年期期间的作用尚不清楚.
研究的目的:
- 研究更年期状态对女性棕色脂肪组织 (BAT) 活动的影响.
- 检查不同绝经阶段的脂肪和估计的BAT活性之间的关系.
主要方法:
- 评估了270名年龄在45-55岁的女性的绝经状态.
- 棕色脂肪组织 (BAT) 活动估计使用红外热学在寒冷暴露后.
- 统计分析包括ANOVA和回归模型,以评估更年期状态,脂肪和BAT活动之间的关系.
主要成果:
- 与绝经前妇女相比,绝经后妇女的BAT活动估计显著低于绝经前妇女.
- 较低的BAT活动与更高的腰部至部周长比率相关,这表明中心脂肪度增加.
- 在更年期组之间没有观察到一般脂肪度的显著差异.
结论:
- 绝经后妇女的棕色脂肪组织 (BAT) 活动减少可能导致中心脂肪积累增加.
- 降低BAT活性与更大的脂肪中心性有关,这表明在绝经后心脏代谢疾病风险增加方面可能发挥作用.
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