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Updated: Jun 13, 2025

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通过PRDM16的代谢重编程驱动了急性骨髓性白血病中细胞氨基酸耐药性的驱动

Junji Ikeda1, Hiroyoshi Kunimoto2, Yusuke Saito3

  • 1Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama.

Haematologica
|June 12, 2025
PubMed
概括

在急性髓性白血病 (AML) 中,高PRDM16表达通过促进线粒体呼吸和MYC激活来驱动细胞因子抗性. 针对这种代谢途径可以克服AML患者的治疗失败.

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