对于患有肠道营养不耐受症的重症儿童的阿莫西西林 (AmoxENI研究):一项随机对照试验
Rania G Abdelatif1, Abanob A Francis1, Elsayed Abdelkreem1
1Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt.
Journal of pediatric gastroenterology and nutrition
|June 12, 2025
概括
氨基显著改善了重症儿童的肠道营养不耐受. 这种治疗导致了更好的营养摄入量和更少的胃肠道症状,表明了潜在的治疗作用.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 临床药理学 临床药理学
- 胃肠病学 胃肠病学
背景情况:
- 肠道营养不耐受 (ENI) 是儿科重症监护室 (PICU) 的一个常见挑战.
- 有效的ENI管理对于改善患者的治疗结果至关重要.
- 临床试验.gov 标识符:NCT05828758.8.gov 临床试验.gov 标识符:NCT05828758.gov 临床试验.gov 临床试验.gov 临床试验.gov 临床试验.
研究的目的:
- 评估阿莫西西林在治疗入院于PICU的儿童中ENI的疗效.
- 评估阿莫西西林对营养摄入量和胃肠道症状的影响.
主要方法:
- 一项随机对照试验,涉及90名儿童 (1个月至12岁) 接受ENI治疗.
- 参与者通过胃管每天三次接受阿莫西西林 (10毫克/公斤) 或安慰剂,持续一周.
- 主要结局:在治疗后的第7天,达到≥2/3的能量需求而没有显著的胃肠道症状.
主要成果:
- 阿莫西西林组在75.6%的患者中实现了主要结果,而安慰剂组为31.1% (RR:2.4,p<0.001).
- 氨基显著增加了肠道营养摄入量 (60%比24%,p<0.001),并减少了吐和腹.
- 在组间的其他次要结果中没有发现显著差异.
结论:
- 阿莫西西林在改善重症儿童的ENI方面表现有前途.
- 需要进一步的研究来确认发现,探索机制,并评估临床效用.
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