体重波动与代谢功能障碍相关的脂肪性肝病风险之间的关联
Jin-Ping Wang1, Jia-Yang Wang1, Pei-Qi Sun1
1Department of Gastroenterology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
World journal of hepatology
|June 12, 2025
概括
体重波动和肥胖增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险,特别是随着年龄的增长. 高强度运动可以减轻那些稳定肥胖的人的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的全球发病率正在上升.
- 运动和体重变化是已知的MASLD风险因素.
- 体重波动强度对MASLD风险的影响需要进一步调查.
研究的目的:
- 检查体重波动模式和身体活动强度与MASLD患病率之间的关系.
- 了解不同的体重变化动态如何影响MASLD风险.
主要方法:
- 分析国家健康和营养检查调查数据 (2009-2018).
- 权重多变量逻辑回归用于评估重量波动效应.
- 非参数的受限制的立方斜线曲线用于非线性重量变化分析.
主要成果:
- 对于那些转向或保持肥胖的人来说,MASLD风险随着年龄的增长而升级.
- 稳定的肥胖症显示了与年龄相关的MASLD患病率;增加体力活动可以降低这种风险.
- 悖论性的MASLD风险上升观察到与强化体力活动在某些时期.
结论:
- 过渡到或维持肥胖会增加MASLD的风险,特别是随着年龄的增长.
- 高强度体力活动在稳定肥胖的个体中提供了对MASLD的保护性益处.
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