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与代谢功能障碍相关的脂肪肝疾病和2型糖尿病的心血管影响:元分析
Sahana Shetty1, Renuka Suvarna1, Vanessa Ambrose Fistus2
1Department of Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
World journal of hepatology
|June 12, 2025
概括
患有代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和2型糖尿病 (T2DM) 的患者面临心血管事件 (CVE) 风险增加. 这一综述强调了T2DM患有MAFLD的患者心脏病发病率较高,强调需要更好的风险分层.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和2型糖尿病 (T2DM) 是独立的心血管疾病 (CVD) 风险因素.
- MAFLD和T2DM的同时存在与心血管疾病风险的扩大有关,需要精确的风险分层.
研究的目的:
- 系统地审查和量化患有同时存在MAFLD和T2DM的患者心血管事件 (CVEs) 和心血管疾病的风险.
- 通过为这一患者群体提供基于证据的风险分层来告知临床实践.
主要方法:
- 使用PubMed,EMBASE和Cochrane图书馆的数据进行了系统性审查和元分析.
- 使用Joanna Briggs Institute (JBI) 工具进行了质量评估,并使用RevMan 5.4软件进行了元分析.
- 对CVE和CVD风险的效果指标以95%置信区间 (CI) 的几率比率 (OR) 表示.
主要成果:
- 分析包括14项研究 (5个队列,9个横截面),共370,013名参与者.
- 在MAFLD组中,在T2DM患者中 (OR 1.28,95% CI 1.04-1.56,P=0.02) 在5-6年内观察到更高的CVEs风险.
- 患有MAFLD的T2DM患者中,心血管疾病的患病率明显高于没有MAFLD的患者 (OR 1.47,95%CI 1.21-1.78,P=0.0001).
结论:
- 在T2DM患者中存在MAFLD显著增加了心血管事件 (CVEs) 的风险.
- 患有MAFLD的T2DM患者表现出更高的心血管疾病 (CVD) 患病率.
- 进一步的大规模,多中心,长期前性研究对于在T2DM患者中准确地分层心血管风险至关重要.
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