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观察和等待的持续发展.

Mikhael Belkovsky1, Ali Alipouriani2, Arielle E Kanters2

  • 1Department of Surgery, University of Massachusetts, Worcester, Massachusetts.

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概括
此摘要是机器生成的。

在新辅助化学辐射治疗 (nCRT) 后使用临床完整反应 (cCR) 的直肠癌观察和等待 (W&W) 方法,显示出高生存率. 这种非手术策略为选定的患者提供了降低的发病率,而不会影响结果.

关键词:
非操作性的管理.这是直肠癌.观察和等待,等待和等待.

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科学领域:

  • 在瘤学瘤学.
  • 手术瘤学手术瘤学
  • 胃肠病学 胃肠病学

背景情况:

  • 观察和等待 (W&W) 是一种正在发展中的直肠癌非手术治疗策略.
  • 它依赖于在新辅助化学辐射治疗 (nCRT) 后实现临床完整反应 (cCR),以预测病理完整反应 (pCR).
  • 随着nCRT疗法疗程效率的提高,W&W已成为某些患者的可行选择.

研究的目的:

  • 审查W&W的直肠癌战略的历史发展和有效性.
  • 根据最近的临床证据,为W&W提供当前的建议.
  • 评估W&W的瘤结果和生活质量影响.

主要方法:

  • 关于直肠癌的W&W的历史和当代研究的文献综述.
  • 对临床试验数据的分析,重点关注应答率和生存结果.
  • 评估患者报告的结果和与W&W相关的发病率.

主要成果:

  • 在nCRT后实现cCR是W&W候选人的pCR可靠指标.
  • 获得cCR的W&W管理的患者显示5年无病生存率为85-92%.
  • W&W提供了显著降低与治疗相关的发病率和改善生活质量的潜力.

结论:

  • 观察和等待策略是安全有效的非手术选择,用于直肠癌患者实现cCR后nCRT.
  • W&W可以保持生活质量,减少外科手术发病率,而不会对生存产生负面影响.
  • 持续的研究和标准化的协议对于优化W&W实施至关重要.