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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
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Updated: Jun 13, 2025

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斯芬哥辛-1-酸盐通路在人类妊娠组织中被差异激活.

Magdaleena Naemi Mbadhi, Hideji Fujiwara, Ruth Gill

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    此摘要是机器生成的。

    在怀孕组织中,sphingosine-1-phosphate (S1P) 代谢和酶的调节方式不同. 在分娩期间肌子膜S1P增加表明肌子膜收缩性起作用.

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    科学领域:

    • 产科和妇科 产科和妇科
    • 生物化学 生物化学
    • 生殖生物学 生殖生物学

    背景情况:

    • 失调的肌体收缩性与产科并发症有关.
    • 氨酸-1-酸盐 (S1P) 是妊娠组织中的炎症调节剂,但其代谢动态尚不清楚.
    • 了解S1P代谢对于解决妊娠并发症至关重要.

    研究的目的:

    • 在人类孕期组织中对神素-1-酸盐 (S1P) 代谢酶和受体表达进行分析.
    • 量化怀孕不同阶段的脂代谢.
    • 调查S1P在肌肉膜收缩性中的作用.

    主要方法:

    • 从没有分娩的期末,有分娩的期末和没有分娩的早产期怀孕中收集了人类的肌子膜, decidua parietalis 和chorioamnion.
    • 通过定量聚合酶链反应评估S1P代谢酶和受体的信使RNA (mRNA) 表达.
    • 量化了使用向液体染色学-并联质谱的脂蛋白.

    主要成果:

    • 斯芬戈辛-1-酸盐 (S1P) 代谢酶和受体在妊娠组织中表达的差异.
    • 宫内膜的S1P受体表达和S1P丰度高于分娩时的决定性和胆子膜.
    • 与没有分娩相比,S1P和SPHK1表达在分娩时的肌子宫显著增加.

    结论:

    • 斯芬哥辛-1-酸盐 (S1P) 的新陈代谢和信号在人类妊娠组织中受到明显的调节.
    • 研究结果表明,S1P在控制肌肉膜收缩性方面可能具有治疗作用.
    • 组织特异性S1P调控提供了对产科并发症机制的洞察.