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禁用PSGL-1消除了在胰腺癌中免疫抑制和对PD-1阻塞的抵抗

Jennifer L Hope, Yijuan Zhang, Hannah A F Hetrick

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
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    在胰腺癌中,P-selectin glycoprotein ligand-1 (PSGL-1) 作为一个检查点. 移除PSGL-1可增强CD8+T细胞活性,控制瘤生长,改善胰腺管道腺癌的免疫治疗反应.

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