通过深度学习发现的蛋白质酶衍生的抗微生物
bioRxiv : the preprint server for biology
|June 12, 2025
概括
研究人员发现了新型的抗微生物,称为来自人类蛋白质组的蛋白质素. 这些具有开发抗药性细菌新疗法的潜力.
科学领域:
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
- 计算生物学 计算生物学
背景情况:
- 人类蛋白质组包含以前未被识别的参与宿主免疫的生物活性.
- 这是一个很棒的节目,这是一个很棒的节目.
- 交叉谈话假设 交叉谈话假设
- 提出了传统免疫作用之外的分子对免疫有积极的贡献.
- 之前的研究已经确定了具有潜在抗微生物活性的蛋白酶衍生.
研究的目的:
- 系统地识别和描述来自人类蛋白质组的新型抗微生物.
- 研究这些的潜力,作为对临床相关病原体的治疗药物.
主要方法:
- 利用深度学习来挖掘ProteasomeDB,寻找潜在的抗菌.
- 使用深度学习模型对11种病原体的抗生素活性预测.
- 鉴定出的的物理化学特性和序列多样性.
主要成果:
- 发现了59种候选抗菌,称为抗菌.
- 蛋白质 蛋白质 蛋白质 蛋白质 蛋白质 蛋白质
- , , , 这是一个很好的方法.
- 平均最低抑制度 (MIC) 的中位数为≤64μmol/L.
- 精制为21种不同序列的蛋白质酶,具有阴离子残留和增强的两性.
- UMAP分析证实蛋白质素与已知的抗微生物不同.
结论:
- 蛋白质体是新型抗微生物的来源,具有潜在的治疗应用.
- 蛋白质素代表了一种新型的先天性免疫.
- 这些发现为开发针对多药耐药病原体的创新治疗提供了基础.
相关概念视频
Antimicrobial Proteins
947
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
947
The Proteasome
818
Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
818
The Proteasome Structure
716
The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
The proteasome is an...
716


