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Updated: Jun 13, 2025

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与自闭症相关的SCN2A缺陷破坏了人类大脑组合体中的皮质-状回路

Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    SCN2A突变破坏人类大脑电路,损害轴突投射和突触传输,导致网络过度刺激. 这项研究揭示了SCN2A相关自闭症谱系障碍中人类特有的脆弱性.

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