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Updated: Jun 13, 2025

Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase
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Published on: February 12, 2019

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在G蛋白β5β-螺旋中引起疾病的突变破坏了其伴介导的折叠轨迹

Mikaila I Sass, Deirdre C Mack, Riley A Nickles

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    在G蛋白β5 (Gβ5) 中的错误突变会破坏其由CCT chaperonin折叠,导致神经系统疾病. 这项研究揭示了这些突变如何将Gβ在非功能状态中捕获,这表明了稳定策略.

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