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相关概念视频

Development of the Heart01:27

Development of the Heart

899
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
899
Development of Blood Vessels01:07

Development of Blood Vessels

542
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
542
Fetal Circulation01:14

Fetal Circulation

851
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
851
Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

1.0K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
1.0K

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相关实验视频

Updated: Jun 13, 2025

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

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产后肺动脉从转录到组织的发展.

Erica L Schwarz, Abhay B Ramachandra, Nicola Yeung

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    此摘要是机器生成的。

    这项研究详细介绍了小鼠的正常产后肺动脉发育,为了解先天性心脏缺陷和手术影响提供了关键数据. 这项研究建立了一个计算模型,用于预测在改变血液动力学条件下的血管变化.

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    Angiogenesis in the Ischemic Rat Lung
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    相关实验视频

    Last Updated: Jun 13, 2025

    Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
    08:02

    Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

    Published on: October 19, 2013

    18.3K
    Angiogenesis in the Ischemic Rat Lung
    07:36

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    Published on: February 8, 2013

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    科学领域:

    • 心血管生物学 心血管生物学
    • 发展生物学 发展生物学
    • 生物医学工程 生物医学工程

    背景情况:

    • 在发育早期,先天性疾病和手术显著改变了肺动脉血液动力学.
    • 病理状况包括 patent ductus arteriosus,肺动脉缩/缩小症,以及低氧化引起的肺高血压.
    • 诸如布拉洛克-托西格分流,格伦,丰坦和诺伍德手术等手术干预措施会影响肺动脉的发育.

    研究的目的:

    • 从生物学和机械的角度研究肺动脉的自然产后发育.
    • 建立对正常肺动脉表型的基本理解,以改善诊断和治疗.
    • 开发一个基于数据的肺动脉发育计算模型.

    主要方法:

    • 从野生类型的小鼠收集了新的数据.
    • 记录了基因表达的出生后变化,血管壁的组成,以及近端肺动脉的生物力学特性.
    • 开发了一个基于经验数据的计算模型.

    主要成果:

    • 肺动脉基因表达的特征性正常产后变化.
    • 在产后发育期间,血管壁组成的详细变化.
    • 临近肺动脉生物机械性质的量化变化.

    结论:

    • 建立了一个数据驱动的计算模型,用于模拟在血液动力学扰动下肺动脉发育.
    • 这些发现为了解先天性心脏病中的肺动脉病理生理学提供了必要的基线数据.
    • 这项研究对于改善受影响患者的诊断,治疗和预后策略至关重要.