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Updated: Jun 13, 2025

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
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SLX4IP与FANCM并行作用,以限制ALT端粒中的BLM依赖的复制应激

Jessica Spindler, Francesca Pandolfo, Anna Eva Koch

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    SLX4IP抑制了BLM驱动的复制应激在替代延长端粒 (ALT) 癌细胞中的端粒. 它的损失导致压力,但在FANCM中产生了合成致命的脆弱性,提供了新的治疗点.

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