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Updated: Jun 13, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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IL-6 通过CRM1-依赖核出口通过KSHV介导的超缩抑制

Samantha Schultz, Jacob Miles, Will Dwyer

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    卡波西卡波西 (Kaposi Kaposi) 是一个

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    Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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    The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
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