相关实验视频

Updated: Jun 13, 2025

Author Spotlight: Unveiling Mitochondrial Contact Sites and Architectural Insights
07:55

Author Spotlight: Unveiling Mitochondrial Contact Sites and Architectural Insights

Published on: June 16, 2023

1.3K

膜阻止了线粒体凝聚物的粗化

Sanjaya V B D Aththawala Gedara, Surya Teja Penna, Marina Feric

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    研究人员开发了一种光激活的工具来研究线粒体凝聚物. 线粒体膜限制了凝结体的大小和动态,影响了它们在细胞器内的行为.

    更多相关视频

    Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging05:29

    Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging

    Published on: January 17, 2025

    812
    Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils00:15

    Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

    Published on: September 28, 2019

    5.9K

    相关概念视频

    Mitochondrial Membranes01:45

    Mitochondrial Membranes

    A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
    9.2K
    The Inner Mitochondrial Membrane01:28

    The Inner Mitochondrial Membrane

    The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
    3.3K
    Mitochondrial Precursor Proteins01:39

    Mitochondrial Precursor Proteins

    Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
    Most of the mitochondrial...
    2.5K
    Mitochondrial Protein Sorting01:39

    Mitochondrial Protein Sorting

    Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
    Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
    4.3K
    Structure of Porins01:21

    Structure of Porins

    Mitochondria, chloroplasts, and gram-negative bacteria have transmembrane, beta-barrel proteins called porins to mediate the free diffusion of ions and metabolites across the membrane. Mitochondrial porin precursors contain conserved amino acid sequences called beta signals at their C-terminal. Beta signals have a  motif of PoXGXXHyXHy (Po-Polar, X-Any amino acid, G-Glycine, Hy-LargeHydrophobic), which are crucial for precursor recognition to initiate precursor assembly. Beta-barrel...
    2.9K
    Translocation of Proteins into the Mitochondria01:19

    Translocation of Proteins into the Mitochondria

    Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
    Sorting of outer membrane proteins:
    Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
    3.1K