相关实验视频

Updated: Jun 13, 2025

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
07:31

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

15.2K

Kv2/Kv6.4异构通道在脊柱运动神经元中表达,并在C-button突触中局部化

Taylor A Lacey, Karl D Murray, James S Trimmer

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    在脊髓运动神经元中发现了电压关闭 (Kv) 通道,特别是Kv2/Kv6.4亚型. 这些通道定位在突触下方的ER-PM连接处,可能调节神经元信号传输.

    更多相关视频

    Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals08:38

    Vibrodissociation of Neurons from Rodent Brain Slices to Study Synaptic Transmission and Image Presynaptic Terminals

    Published on: May 25, 2011

    15.5K
    Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes10:19

    Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

    Published on: January 10, 2011

    20.9K

    相关概念视频

    The Role of Ion Channels in Neuronal Computation01:19

    The Role of Ion Channels in Neuronal Computation

    A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
    Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
    3.2K
    Voltage-gated Ion Channels01:26

    Voltage-gated Ion Channels

    Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
    Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
    8.0K
    The Neuromuscular Junction01:19

    The Neuromuscular Junction

    The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
    9.4K
    Spinal Cord: Information Processing01:10

    Spinal Cord: Information Processing

    The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
    Sensory Information Processing
    Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
    1.2K
    Neuromuscular Junction And Blockade01:29

    Neuromuscular Junction And Blockade

    The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
    3.0K
    Action Potential01:31

    Action Potential

    Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
    Membrane potential in neurons
    Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
    7.9K