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Updated: Jun 13, 2025

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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Published on: February 17, 2023

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通过Adar1p150的Zα域进行Z型稳定对A-to-I编辑有微妙的影响

Parker J Nichols, Kent A Riemondy, Jeffrey B Krall

    bioRxiv : the preprint server for biology
    |June 12, 2025
    PubMed
    概括

    作用于RNA 1 (ADAR1) 的腺氨酸脱氨酶的Zα域在A-to-IRNA编辑中起小作用. Zα突变体中的表型可能源于与Z-DNA结合蛋白1 (ZBP1) 的改变相互作用,而不是RNA编辑变化.

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