对冲动性和冒险性特征的基因组结构方程建模揭示了三种与大脑结构和发育明显相关的潜在因素
bioRxiv : the preprint server for biology
|June 12, 2025
概括
遗传因素影响冲动和冒险,影响儿童的大脑发育. 这些遗传倾向与特定的大脑结构有关,并由社会经济地位调节,为神经发育途径提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 发展心理学 发展心理学
背景情况:
- 冲动性是一种复杂的童年特征,与ADHD和药物使用障碍等精神疾病有关.
- 基因组和神经成像研究表明,遗传和大脑系统与冲动和冒险有关.
- 了解遗传基础的重叠及其与早期大脑形态学相关的关联至关重要.
研究的目的:
- 研究冲动性和冒险性特征的重叠遗传结构.
- 检查早期发育中的遗传因素与大脑结构之间的关联.
- 为了确定社会经济地位是否调节这些遗传-大脑关联.
主要方法:
- 基因组结构方程建模应用于17个GWAS数据集的冲动性和风险承担.
- 在青少年大脑认知发育研究队列中确定了遗传因素的多基因分数 (PGS) 的计算 (n=4,142).
- 分析PGS与大脑结构之间的关联,以社会经济地位作为调节者.
主要成果:
- 发现了三个遗传潜伏因素:缺乏自我控制,奖励驱动和寻找感觉.
- 这些因素与额叶皮质,皮下细胞和白质结构之间发现了明显的关联.
- 社会经济地位调节了PGS缺乏自我控制和白质平均扩散性之间的关联.
结论:
- 对冲动和冒险的遗传倾向与幼儿时期 (9-10岁) 的形态大脑差异相关.
- 冲动性的多维性质是理解其神经发育基础的关键.
- 这些发现突出了早期对大脑结构的遗传影响,与行为特征有关.
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