在学习和消费行为过程中,MCH神经元对accumbens多巴胺的双向调节
bioRxiv : the preprint server for biology
|June 12, 2025
概括
在食物学习过程中,黑色素缩激素 (MCH) 和多巴胺 (DA) 系统共同激活. MCH神经元双向调节DA释放,影响养行为和关联.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 行为神经科学 行为神经科学
背景情况:
- 感官提示奖励关联对于生存至关重要,但可以在现代环境中导致过度饮食.
- 下丘脑中的黑色素缩激素 (MCH) 神经元与激发性养和协会形成有关.
- 在MCH和中临界多巴胺 (DA) 之间的相互作用是MCH在 hedonic 养和调节中的作用的潜在机制.
研究的目的:
- 描述在养期间MCH神经元和DA传输之间的体内相互作用以及以食物为动机的帕夫洛夫式调节.
- 调查MCH系统在DA释放时的时间动态和调制能力.
主要方法:
- 在动物体内利用纤维光度测量来测量MCH神经元活动和DA释放.
- 侧向下丘脑/不确定区域 (LH/ZI) 和内核 (NAc),特别是中间外 (mNAcSh) 的有针对性的测量.
- 使用了MCH系统的功能增益和丧失操纵.
主要成果:
- 在mNAcSh中,MCH神经元活动和DA释放在食物消耗期间和响应奖励线索时被协同激活.
- 在消费过程中,DA释放先于MCH活动;在提示反应过程中,MCH活动先于DA释放.
- 调节MCH系统在mNAcSh中双向改变了DA释放的方向.
结论:
- 在食物激发的学习过程中,MCH和DA系统的生理联合激活发生.
- 在mNAcSh中,MCH系统对DA释放进行双向控制.
- 这些发现阐明了一个关键的神经回路,它是动机行为和协会学习的基础.
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