一个树突细胞群体,负责转谷氨酸酶2介导的谷氨酸抗原呈现在腹腔疾病中
bioRxiv : the preprint server for biology
|June 12, 2025
概括
肠道中的树突细胞 (DCs) 使用转质氨酶2 (TG2) 和LRP1来处理谷蛋白抗原,驱动乳病 (CeD). 这种TG2/LRP1通路在人体单细胞中也活跃,在活跃的CeD中,特定的DC子集升高.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 细胞生物学 细胞生物学
背景情况:
- 性疾病 (CeD) 是一种由质引发的自身免疫性疾病.
- 转氨酶2 (TG2) 和HLA-DQ2是向T细胞呈现脱胺质抗原的关键参与者.
- 对于CeD中致病性TG2和DQ2活性负责的特定细胞尚不清楚.
研究的目的:
- 为了阐明致病性TG2和DQ2在乳病中的细胞源.
- 研究质抗原在肠道中被加工和呈现的机制.
- 为了确定活性CeD的潜在生物标志物.
主要方法:
- 利用化学生物学工具研究TG2和LRP1相互作用.
- 采用DQ2-转基因小鼠模型来跟踪抗原呈现和免疫细胞迁移.
- 在CeD患者中分析了人体外周血液单细胞和树突细胞子集.
主要成果:
- 肠道CD103+树突细胞 (DCs) 使用细胞表面TG2和LRP1受体去胺和缩质抗原.
- 这些带有抗原的DC迁移到淋巴结,启动T细胞的参与,并上调肠道TG2活性.
- TG2 / LRP1通路在人类CD14+单细胞中活跃,在活跃的CeD患者中,肠回归DC子集升高.
结论:
- CD103+ DCs在CeD中的质抗原处理和呈现方面至关重要.
- 单细胞和DC中的TG2/LRP1通路提供了对质毒性机制的见解.
- 在CeD患者中增加的肠回归DC子集表明潜在的诊断或预后作用.
相关概念视频
T Cell Activation and Clonal Selection
686
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
686
Antigens Involved in Adaptive Immunity
470
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
470
T Cell Types and Functions
960
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
960
Antigen Presenting Cells
1.7K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.7K
Cell-mediated Immune Responses
67.8K
Overview
67.8K
Antigen Processing Pathways
956
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
956


