在NOVELTY中的喘和/或COPD患者中绘制SGRQ的EQ-5D-5L得分
Dan Jackson1, Anna Quinton2, Fanni Zhang3
1Statistical Innovation Group, AstraZeneca, Cambridge, UK.
Pragmatic and observational research
|June 12, 2025
概括
使用额外的共变量将圣乔治呼吸道问卷 (SGRQ) 映射到EQ-5D-5L,显示慢性阻塞性肺病 (COPD) 和喘患者的表现类似.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 卫生经济学 卫生经济学
- 生物统计学 生物统计学
背景情况:
- 圣乔治呼吸道问卷 (SGRQ) 评估了阻塞性呼吸道疾病的健康状况.
- EQ-5D-5L是一个基于偏好的公用事业措施.
- 斯塔基和其他人. 开发了一种算法,将SGRQ映射到COPD的EQ-5D-5L,使用有限的共变量.
研究的目的:
- 为了评估是否添加共变量可以改善Starkie等人. 算法用于将SGRQ映射到EQ-5D-5L.
- 为了确定算法是否可以扩展到喘和喘+COPD患者.
主要方法:
- 通过使用NOVELTY研究 (NCT02760329) 的数据,安装了六个纵向线性混合模型.
- EQ-5D-5L是响应变量,测试了不同的共同变量组合.
- 在一个验证样本中,使用平均平方误差 (MSE) 评估模型性能.
主要成果:
- 模型与不同共变量组的类似小微企业表现良好 (年2:0.0302-0.0308;年3:0.0272-0.0277).
- 性能与斯塔基等人的性能相当. 在喘和COPD亚组中一致.
- 在验证样本中,解释的差异为45-48%.
结论:
- 斯塔基等人使用的原始共变量. 足以将SGRQ映射到喘和/或COPD中的EQ-5D-5L.
- 使用NOVELTY系数开发的算法扩大了这种映射的适用性,使其适用于患有慢性呼吸道疾病的更广泛的人群.
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