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高压氧治疗与慢性伤口负压伤口治疗相结合的高压氧疗法的有效性:一项随机对照试验

Thanaporn Riansrithongkham¹, Pangrum Yongchareon², Ajana Sivadechathep²

¹Division of Plastic and Reconstructive Surgery, Department of Surgery, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.

|June 12, 2025

概括

将负压伤口疗法 (NPWT) 与高压氧气疗法 (HBOT) 结合起来,可显著加快慢性伤口愈合. 与单独的NPWT相比,这种综合方法可以提高愈合率,而不会增加疼痛或细菌污染.

科学领域:

伤口治愈研究研究伤口治愈研究
再生医学是一种再生医学.
临床试验临床试验

背景情况:

慢性伤口对患者和医疗保健系统造成重大负担.
目前的慢性伤口治疗缺乏普遍认可的标准方法.
负压伤口疗法 (NPWT) 和高压氧气疗法 (HBOT) 是已知的治疗方法,但它们的联合疗效正在研究中.

研究的目的:

评估结合HBOT与NPWT在慢性伤口治疗中的有效性.
为了比较组合疗法和单独的NPWT之间的伤口愈合率.
评估二次结果,包括疼痛和细菌污染.

主要方法:

进行了一项前性的多中心随机对照试验.
患有需要NPWT的慢性伤口的患者随机分为两组:NPWT+HBOT和单独NPWT.
伤口愈合率,疼痛评分和细菌污染是主要和次要结果措施.

主要成果:

与仅使用NPWT的组 (P=0.001) 相比,NPWT+HBOT组在多个时间点 (第3,6,9和12天) 显示出明显更高的伤口愈合率.
观察到特定的愈合率差异:第3天的11.81%与8.54%相比,在第12天增加到20.15%与14.9%.
治疗组之间没有发现疼痛评分或细菌污染的统计学上显著差异.

结论:

结合NPWT和HBOT的疗法显著提高慢性伤口的愈合率.
将HBOT添加到NPWT中不会对疼痛水平产生不利影响,也不会增加细菌污染.
结合NPWT和HBOT是一种有前途的治疗策略,可以加速慢性伤口愈合.

关键词:

高压氧疗法高压氧疗法负压伤口治疗疗法负压伤口治疗

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