维斯纳金治疗通过调节炎症,氧化,压力和粘膜损伤来减轻DSS诱导的大肠炎
Vemula Sravathi1, Madhuri Doppalapudi1, Ravi Kumar Yadala1
1Department of Veterinary Pathology, P.V. Narsimha Roa Telangana Veterinary University, Hyderabad, Telangana, India.
Frontiers in veterinary science
|June 12, 2025
概括
维斯纳金 (VIS) 通过减少炎症和改善小鼠模型中的肠道屏障功能,有效治疗性结肠炎 (UC). 这种天然化合物显示出作为UC患者的替代疗法的希望.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,影响结肠.
- 目前的治疗方法有局限性,需要寻找新的治疗药物.
- 维斯纳金 (VIS) 是一种天然的色素,具有潜在的抗炎性质.
研究的目的:
- 在硫酸 (DSS) 诱导的性结肠炎 (UC) 的小鼠模型中研究维斯纳金 (VIS) 的治疗效果.
- 评估VIS对UC的紧结蛋白表达,氧化应激,亡和炎症的影响.
- 评估VIS作为UC的潜在替代治疗方法.
主要方法:
- 建立了一个DSS诱导的UC小鼠模型,用36只雄性C57BL/6小鼠分成六组.
- 治疗组接受了不同剂量的VIS,DSS或甲.
- 通过临床症状,体重,结肠长度,DAI,氧化应激标志物,细胞因子水平和组织病理学来评估疾病进展和治疗结果.
主要成果:
- 在接受DSS治疗的小鼠中,给予VIS,特别是高剂量,显著降低了体重减轻和结肠缩短.
- 在VIS治疗下降了氧化和化压力标志物 (亚酸盐,MDA) 和抑制了促炎性细胞因子 (TNF-α,IL-1β,IL-6,IL-17).
- 维斯通过上调奥克卢丁表达和减弱结肠病变来增强肠道屏障的完整性.
结论:
- 维斯纳金 (VIS) 在UC小鼠模型中显示出显著的抗炎和粘膜保护作用.
- VIS调节炎症通路并改善肠道屏障功能,这表明它对UC的治疗潜力.
- 作为治疗性结肠炎的安全和有效替代疗法候选者,VIS具有前途.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
130
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
130
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
324
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
324
Drugs for Treatment of Diarrhea-Predominant IBS
153
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
153
Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118
Inflammatory Bowel Disease V: Surgical Management
128
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
128
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
145
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
145


