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结直肠癌患者的营养和炎症指标在具有不同的微卫星稳定状态的结直肠癌患者之间有所不同

Hao Zuo¹, Zheng Yuan¹, Meng-Hui Gu¹

¹Department of Gastrointestinal Surgery, Suzhou Municipal Hospital, Affiliated Suzhou Hospital of Nanjing Medical University, Gusu school of Nanjing Medical University, Suzhou 215000, Jiangsu Province, China.

World journal of gastrointestinal surgery

|June 12, 2025

概括

微卫星不稳定性 (MSI) 和微卫星稳定性 (MSS) 的结直肠癌 (CRC) 的营养和炎症标志物不同. 这些指标可以帮助CRC治疗和健康管理.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
营养科学营养科学

背景情况:

营养和炎症标志物对于评估癌症患者的健康和免疫功能至关重要.
这些因素与结直肠癌 (CRC) 的诊断和治疗密切相关.

研究的目的:

研究CRC患者的营养/炎症指标和微卫星稳定性 (MSS) 状态之间的关系.

主要方法:

分析了56名CRC手术患者的临床数据.
评估了营养指标 (血清白蛋白,甘油三,胆固醇,BMI) 和炎症标记 (中性粒细胞,淋巴细胞,单细胞,中性粒细胞与淋巴细胞的比率,淋巴细胞与单细胞的比率).
研究了与微卫星不稳定 (MSI) 状态的相关性.

主要成果:

与MSS瘤相比,MSI瘤患者的血清白蛋白和BMI较低 (P <0.05).
与MSS组相比,MSI组的绝对淋巴细胞数量显著降低,中性粒细胞与淋巴细胞的比率更高 (P <0.05).
这些发现表明MSI和MSSCRC之间有明显的炎症和免疫特征.

结论:

具体的营养和炎症指标显示MSI和MSSCRC患者之间存在显著差异.
这些标记物在CRC亚群中具有临床治疗和健康管理的潜力.

关键词:

结肠直肠癌是一种癌症.诊断诊断诊断诊断诊断炎症指数是指炎症指数.微卫星的不稳定性是微观的营养指标营养指标瘤标志物瘤标志物

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