新的炎症营养预后指数用于经过胃切除术的晚期胃癌患者和预防性高热性腹腔内化疗
Liang Wang1,2, Mei-Zhu Chen3, Lei Liu1
1Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266555, Shandong Province, China.
炎症和营养状况显著影响了接受高温腹腔内化疗 (HIPEC) 的晚期胃癌 (AGC) 患者的预后. 一个新的名录模型有助于预测结果和个性化治疗策略,以获得更好的结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 预防性高热性腹腔内化疗 (HIPEC) 用于晚期胃癌 (AGC),以预防腹腔转移.
- 在HIPEC后的患者预后有所不同,需要对影响因素进行进一步的调查.
研究的目的:
- 为了确定炎症和营养指标是否会影响胃切除术后的AGC患者预后和预防性HIPEC.
- 开发一种新的炎症营养预后指数 (INPI).
- 为预测预后和指导临床决策创建一个名ogram.
主要方法:
- 对经过胃切除术和预防性HIPEC的181名AGC患者的回顾性分析.
- 使用LASSO考克斯回归来构建INPI.
- 使用卡普兰-梅尔,日志等级测试和考克斯回归模型进行生存分析和预后因素识别.
- 通过引导方法生成并验证了一个预后名录.
主要成果:
- 该研究确定了炎症和营养指标以及患者预后之间的关联.
- 一个预后性诺摩格拉姆成功开发和验证.
- 诺米图包含INPI和临床特征来预测结果.
结论:
- 炎症和营养状况是AGC患者进行胃切除术的关键预后因素.
- 开发的名录,结合INPI,为个性化治疗策略提供了一个工具.
- 这种方法旨在改善接受这种联合治疗的AGC患者的整体预后.
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