环境丰富对肠道微生物群的压力诱导变化的调节效应
Kevin B Smith1, Michael Murack1, James Butcher2
1NISE Lab, School of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, ON, Canada.
Brain, behavior, & immunity - health
|June 12, 2025
概括
环境丰富和社会住房调节小鼠的免疫和压力反应,在暴露于LPS后对男性和女性的肠道微生物群产生不同的影响.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 环境丰富 (EE) 影响压力和免疫反应.
- 住房对压力诱导的肠道微生物组变化的影响尚不清楚.
研究的目的:
- 调查贫困 (DH),社会 (SH) 和丰富 (EE) 住房对免疫,HPA轴和肠道微生物群对小鼠脂多糖 (LPS) 的反应的影响.
- 探索这些反应在青春期压力敏感时期的性别特异性差异.
主要方法:
- 180只雄性和雌性小鼠在DH,SH或EE条件下住了3周.
- 小鼠在6周大时接受了盐水或LPS治疗.
- 中央/外围免疫反应,HPA轴标记 (GR,MR) 和肠道微生物群多样性在死后被分析.
主要成果:
- 与DH相比,EE和SH住房导致LPS后更高的血促炎细胞因子 (TNFα,IL6,IL12),男性显示的水平高于女性.
- 住房EE增加了下丘脑和海马体的葡萄糖皮质体受体 (GR) 和矿物质皮质体受体 (MR) 表达.
- 晚期PS治疗诱导了特定性别的肠道微生物群β多样性,在EE和SH条件下,男性表现出更大的多样性.
结论:
- 住房条件显著调节了对LPS的急性免疫和压力反应.
- 环境丰富和社会住房可以以性别特定的方式改变HPA轴调节和肠道微生物组合.
- 这些发现强调了青春期环境,压力,免疫力和肠道微生物群之间的相互作用.
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